JAK stands for Janus kinase. This is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. The JAK-STAT signaling pathway transmits information from chemical signals, through STAT activation, into gene promoters on the DNA activating the DNA transcription.
Cell cycle control: G1/S checkpoint. G2/M damage checkpoint.
Translational control: mTOR. Translational control overview. Regulation of elF4E and p70 S6K. Regulation of elF2.
Apoptosis signaling pathways: Regulation of Apoptosis Overview. Inhibition of Apoptosis. Death receptor signaling. Mitochondrial control of apoptosis.
Chormatin regualtion: Histone Lysine Methylation. Protein Acetylation. Examples of crosstalk between post-translational modifications.
Histones have been shown to be dynamic proteins, undergoing multiple types of post-translational modifications. In this pathway presented by Cell signaling you will find a brief description of the main histone modifications, both in the transcriptionally active and inactive chromatin.
Mitogen-activated protein kinases (MAPK) are a family of protein kinases involved in cell proliferation, cell differentiation, cell movement, and cell death. MAPK signaling cascades are organized hierarchically where: -MAPKs are phosphorylated and activated by MAPK-kinases (MAPKKs), -MAPKKs are phosphorylated and activated by MAPKK-kinases (MAPKKKs). -MAPKKKs are in turn activated by interaction with the family of …
The TGF-beta 1 (Transforming growth factor beta) is the first member of a large group of proteins included in the TGF-beta superfamily. This superfamily includes the activin/inhibin family, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs) and the TGF-beta subfamily. Members of the TGF-beta superfamily interact with cell surface protein kinase receptors to activate Smad …
The Akt cascade works through receptor tyrosine kinases, integrins, B and T cell receptors, cytokine receptors, G protein coupled receptors and other stimuli that induce the production of phosphatidylinositol 3,4,5 triphosphates (PtdIns(3,4,5)P3) by phosphoinositide 3-kinase (PI3K). There are three highly related isoforms of Akt (Akt1, Akt2, and Akt3), being the major signaling arm of PI3K.
Transcription factor Tubby. You can use this tool clicking here